Coagulation Factor XIIa

《英文msh詞典》Coagulation Factor XIIa
[同義詞] Coagulation Factor XIIa
[主題詞] Factor XIIa
[中文釋義] 凝血因子Ⅻ a
[英文釋義] Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation,kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein,plasmin,and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.